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The role of Akt / protein kinase B in healthy and hypertrophied heart
Heleš, Mário ; Žurmanová, Jitka (advisor) ; Hrdlička, Jaroslav (referee)
Protein kinase B, or Akt kinase is expressed in almost all tissues. Two main isoforms in heart are Akt1 and Akt2, which are responsible for regulation of metabolism, growth and survival of cardiomyocytes. Akt kinase is among other pathways stimulated by insulin receptor and mechanoreceptor cascades and its main targets are mTORC1, AMPK and GSK- 3β. Akt kinase is activated in presence of chronic hemodynamic overload of heart. In dependence of intensity and duration of overload, Akt participate in triggering of either adaptive, fully reversible hypertrophy or detrimental irreversible form of hypertrophy, which causes impairment of pumping function of heart and can lead to heart failure. Many more factors with complex interactions participate in cardiac hypertrophy beside Akt kinase. Key words: heart, hypertrophy, Akt/protein kinase B, cardiac remodeling, insulin- like growth factor
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The role of Akt / protein kinase B in healthy and hypertrophied heart
Heleš, Mário ; Žurmanová, Jitka (advisor) ; Hrdlička, Jaroslav (referee)
Protein kinase B, or Akt kinase is expressed in almost all tissues. Two main isoforms in heart are Akt1 and Akt2, which are responsible for regulation of metabolism, growth and survival of cardiomyocytes. Akt kinase is among other pathways stimulated by insulin receptor and mechanoreceptor cascades and its main targets are mTORC1, AMPK and GSK- 3β. Akt kinase is activated in presence of chronic hemodynamic overload of heart. In dependence of intensity and duration of overload, Akt participate in triggering of either adaptive, fully reversible hypertrophy or detrimental irreversible form of hypertrophy, which causes impairment of pumping function of heart and can lead to heart failure. Many more factors with complex interactions participate in cardiac hypertrophy beside Akt kinase. Key words: heart, hypertrophy, Akt/protein kinase B, cardiac remodeling, insulin- like growth factor
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